Adaptive Copy Number Evolution in Malaria Parasites (original) (raw)
Figure 6
The _dhfr_-164L resistance mutation is associated with gch1 CNP in Thailand.
(a) Thai parasites were ranked by gch1 CNP. Error bars show 95% CI around copy number estimates. Open black circles or closed red circles indicate isolates carrying 164I or 164L at dhfr. (b) Association between 55 polymorphic sSNPs and gch1 CNP. Raw _p_-values from t-tests of log transformed copy number estimates are plotted; very similar p-values were obtained from non-parametic Mann-Whitney U-tests using untransformed copy number estimates. Dotted horizontal lines show thresholds for significance following Bonferroni correction for multiple testing. The bars show the strength of associations between gch1 CNP and _dhfr_-I164L (solid red), between polymorphic SNPs in dhfr (N51I) and dhps (S436A, K540E, A581G) (open red bars), and between 55 sSNPs (black). There was only one SNP (MAL04-469608) other than dhfr-164L that crossed the Bonferroni-corrected threshold of p<0.05.