Genetic Mechanisms in Apc-Mediated Mammary Tumorigenesis (original) (raw)
Figure 2
Histological heterogeneity in mammary tumors from K14-cre; ApcCKO/+ female mice.
(A–E) Acinar tumor. (F–J) Basosquamous tumor with squamous metaplasia and ghost cells indicated by arrowheads. (K–O) Pilar tumor with extensive keratinization. (P–T) Undifferentiated tumor. (U–Y) Mammary tumor from a multiparous WAP-cre; ApcCKO/CKO female mouse. Stained with H&E for histology (A, F, K, P, U), K14 (B, G, L, Q, V), α-SMA (C, H, M, R, W), K8 (D, I, N, S, X) and Ki67 (E, J, O, T, Y) antibodies as indicated at the top. Note the different patterns of cell lineage markers associated with different tumor descriptors. Scale bars are 100 µm for K–O, the rest are 50 µm.