Evolutionary Mirages: Selection on Binding Site Composition Creates the Illusion of Conserved Grammars in Drosophila Enhancers (original) (raw)
Figure 2
Turnover rates vary widely in proportion to information content of transcription factor binding site model.
The log of the half-life of different artificial and real binding sites against their specificity. Synthetic binding sites are plotted in gray, while sites derived from Drosophila transcription factors are highlighted: Krüppel (blue circle), Bicoid (red triangle), Giant (green diamond), and Hunchback (cyan hexagon). Specificity is defined as the difference in the information between the binding site and a random sequence of the same length.