Deletion of the Huntingtin Polyglutamine Stretch Enhances Neuronal Autophagy and Longevity in Mice (original) (raw)
Figure 4
ΔQ-htt expression in Hdh140Q/ΔQ mice normalizes the increased lipofuscin accumulation that is observed in the Hdh140Q/+ brain.
(A) Confocal images of the parietal cortex and striatum from one year old HdhΔQ/+, Hdh140Q/+, and Hdh140Q/ΔQ mice (n = 4 of each genotype). Lipofuscin deposits are yellow (white arrowheads), and nuclei are stained with To-Pro-3 (blue). Scale bar = 25 µm. (B) Lipofuscin deposits at 4 months, 6 months, 1 year, and 2 years of age in wild-type (+/+), HdhΔQ/+, Hdh140Q/+, and Hdh140Q/ΔQ parietal cortex and striatum were quantified by measuring their pixel area/field (mean ± s.e.m.). *P<0.05, **P<0.001.