Genome-Wide Association Study in Asian Populations Identifies Variants in ETS1 and WDFY4 Associated with Systemic Lupus Erythematosus (original) (raw)
Figure 5
Allelic expression of ETS1 on SNP rs1128334 in PBMC of healthy individuals.
PBMC cDNA processed from 33 healthy individuals heterozygous on rs1128334 were used for allelic expression detection of ETS1 by pyrosequencing. (A) A case example of detection on the “A” allele and the “G” allele from both DNA and cDNA samples from the same individual. (B) The ratio of G/A allelic detection for both DNA and cDNA samples. The median G/A ratio for DNA is 1.09 (95% CI: 1.08–1.11) and the median G/A ratio for cDNA expression is 1.32 (95% CI: 1.21–1.43), P<0.0001 by paired student's t test.