Candidate Causal Regulatory Effects by Integration of Expression QTLs with Complex Trait Genetic Associations (original) (raw)
Figure 1
Excess of regulatory variants among GWAS signals.
QQ plot depicting the excess of significant regulatory signal in GWAS data (976 NHGRI SNPs). For both the cis and trans analyses, the −log10(P-value) of the best associations per SNP are plotted. In red, the distribution of these values for GWAS SNPs is compared to that of the median of 1,000 sets of 976 random SNPs with same MAF distribution. In black, the estimated upper limit of the 95% confidence interval is plotted.