Candidate Causal Regulatory Effects by Integration of Expression QTLs with Complex Trait Genetic Associations (original) (raw)
Figure 5
RTC score properties when varying D'.
Simulation results depicting the relationship between the RTC score and the D' (eQTL, dSNP) when they tag different causal SNPs (H0: left panel) versus one causal SNP (H1: right panel). D' is not correlated with RTC, therefore it will not determine high scores on its own in the absence of a common functional variant. Under the H1, the majority of high RTC scoring pairs have high D', but in the case of a perfect historical correlation scenario, it's impossible to distinguish causal from coincidental effects with D' only.