Ablation of Whirlin Long Isoform Disrupts the USH2 Protein Complex and Causes Vision and Hearing Loss (original) (raw)
Figure 11
Schematic diagrams illustrate the USH2 multi-protein complex at the PMC in photoreceptors.
(A) Localization of the complex of whirlin (red), usherin (green) and VLGR1 (yellow) at the PMC in mammalian photoreceptors. On the left is a whole-cell view. On the right are the enlarged longitudinal and cross-sectional views. (B) The interactions among whirlin, usherin and VLGR1. PR, proline-rich region; LamGL, LamG-like jellyroll fold domain; LamNT, laminin N-terminal domain; EGF-Lam, laminin-type epidermal growth factor-like domain; FN3, fibronectin type 3 domain; LamG, laminin G domain; PBD, PDZ-binding motif; Calx-β, domains in Na-Ca exchangers and integrin-beta4; PTX, pentraxin domain; EPTP, epitempin domain.