Mice with Alopecia, Osteoporosis, and Systemic Amyloidosis Due to Mutation in Zdhhc13, a Gene Coding for Palmitoyl Acyltransferase (original) (raw)
Figure 6
Histopathological analysis of amyloids in different organs of the affected mice.
Amyloid deposition in sinusoids and around the portal vein in liver (A); in red pulp and peri-white pulp area in spleen (B). In kidney, amyloid was found in glomerulus (C) and renal tubules (D). Amyloid was also found in adrenal cortex and medulla (E), islet of Langerhans and around the acinar cells of pancreas (F), salivary glands (G) and myocardium (arrows in H). All sections were stained with Congo red; amyloid deposits appeared pink-red color with this staining. Bar = 100 µm.