A Missense Mutation in a Highly Conserved Alternate Exon of Dynamin-1 Causes Epilepsy in Fitful Mice (original) (raw)
Figure 3
Fitful and compound heterozygous Dnm1 seizure and locomotor phenotypes.
Shown is the frequency of fitful homozygous (Dnm1Ftfl/Dnm1Ftfl) and compound heterozygous (Dnm1Ftfl/Dnm1tm1Pdc) mutant mice and their respective seizure incidence and locomotor phenotypes. The fitful homozygotes shown were from fully informative matings from the mapping cross used to map the recessive phenotype; the compound heterozygotes were from crosses between single heterozygotes from respective FVB-fitful and B6-null colonies. The asterisk is used to indicate that the latter population was observed almost daily from P12 through demise (P16–P23), whereas the former were observed at weaning age only – suggesting that death occurred in these mutants between P12 and P21.