Orphan CpG Islands Identify Numerous Conserved Promoters in the Mammalian Genome (original) (raw)
Figure 6
Somatic methylation is incompatible with H3K4me3 and RNAPII occupancy at orphan CGIs.
(A) Composite box plots showing sequence read density for brain RNAPII (orange), brain H3K4me3 (green), cerebellum MAP (red) and cerebellum CAP (blue) in mouse. Plotted as for Figure 3D. (B) Sequence profiles of CAP, MAP, H3K4me3 and RNAPII for mouse (chr11: 104,982,000–105,056,000) in ES cells and sperm (left panel) and brain and cerebellum (right panel) depict the loss of RNAPII and H3K4me3 associated with a gain of DNA methylation in cerebellum. Sequence profiles are colour coded as for (A).