Expression of Linear and Novel Circular Forms of an INK4/ARF-Associated Non-Coding RNA Correlates with Atherosclerosis Risk (original) (raw)
Figure 5
ANRIL4-6 and 14-5 correlate with INK4/ARF expression and rs10757278 genotype in human PBTLs.
A, Taqman anlaysis of ANRIL and INK4/ARF transcripts was conducted and normalized as described in Materials and Methods. Correlations between ANRIL and INK4/ARF transcripts in 106 primary peripheral blood T-lymphocytes (PBTLs) were determined using linear regression. The R value for each pair-wise comparison is shown, with those achieving significance (p<0.05) depicted in blue. Due to limitations in sample availability, ANRIL 1-2 and ANRIL 14-5 levels were determined in only a subset of individuals (n = 94 and 98, respectively). B, The relative expression of ANRIL1-2, 14-5 and 18-19 normalized as in ‘A’ is plotted versus rs10757278 genotype. p-values were determined by a two-sided t-test.