Tsx Produces a Long Noncoding RNA and Has General Functions in the Germline, Stem Cells, and Brain (original) (raw)
Figure 7
Tsx deletion affects behavior and short-term hippocampal-dependent memory consolidation in male mice.
(A) Open field test for the total distance traveled for wildtype (n = 9) and Tsx −/Y (n = 9) animals. (B) Open field test for ambulatory counts for the same group of male animals. (C) Open field test quantifying the amount of time spent in the center (Zone 1) of the chamber. * indicates P<0.05 for one-way ANOVA tests. (D) Conditioning response curve for fear conditioning tests for wildtype (n = 5) and Tsx −/Y (n = 7). (E) Contextual fear conditioning tests for 1 h and 24 h after training. The mean percentage of time spent freezing for two independent experiments is shown, for both wildtype (n = 10) and Tsx −/Y (n = 12) male animals. (F) Cued fear conditioning tests. The same groups of animals were tested in novel environmental chambers 48 hr after training (for two independent experiments). The mean percentage of time spent freezing is shown for animals before tone presentation (“pre-CS”) and during the phasic presentation of the tone (“CS”).