Epigenome-Wide Scans Identify Differentially Methylated Regions for Age and Age-Related Phenotypes in a Healthy Ageing Population (original) (raw)
Figure 3
Examples of age and age-related phenotype DMRs in the discovery and replication samples.
(A) Example of an a-DMR probe (cg00468146 in ID4), which also has _cis_-meQTLs. Individuals are coloured according to _cis_-meQTL rs12660828 genotype (AG = red, GG = blue). (B) MZ twin methylation difference analyses identify potential environmentally-triggered DMR cg01136458 in CSMD1 associated with LDL. MZ co-twins are linked by dark blue (positive DMR effect) or light blue (negative DMR effect) dashed lines. (C,D) The two most associated a-DMRs (in NHLRC1 (C) and IRX5 (D)) in the discovery sample of 172 individuals (black dots) also replicate in the sample of 44 younger individuals (red triangles). Dashed lines represent estimated effects within the discovery (black) and replication (red) sample.