Dnmt3a Protects Active Chromosome Domains against Cancer-Associated Hypomethylation (original) (raw)
Figure 1
Overview of the experimental system used for this study.
(A) Representative photographs of lungs from Dnmt3a wildtype and Dnmt3a deficient mice. Dnmt3a deficient mice have more advanced lung tumors. (B) Histophathology of two large Dnmt3a wildtype (wt) and two large Dnmt3a deficient tumors (KO). wt1: intermediate grade, solid growth pattern; wt2: intermediate to high grade, solid growth pattern; KO1: intermediate grade, papillary growth pattern; KO2: high grade, papillary growth pattern. Scale bars: 100 µM. (C) Schematic illustration of relevant comparisons for the characterization of methylation changes.