Rtt109 Prevents Hyper-Amplification of Ribosomal RNA Genes through Histone Modification in Budding Yeast (original) (raw)
Figure 1
Structure of rDNA region in budding yeast.
rARS and RFB are the replication origin and blocking site, respectively. IGS 1 and 2 are intergenic spacers. E-pro is a bidirectional promoter for noncoding transcription. Arrows indicate the direction of transcription of the 5S and 35S rRNA genes. The fork-blocking protein, Fob1p binds to the replication fork blocking site (RFB) in the IGS1, and inhibits the replication fork passing from the left in the figure. Sir2 represses transcription from E-pro.