Influenza Virus Drug Resistance: A Time-Sampled Population Genetics Perspective (original) (raw)
Figure 4
_Ne_-based Approximate Bayesian Computation for the H275Y resistance mutation in the presence of oseltamivir.
For 10'000 simulated trajectories (out of the 100'000 simulations performed), we plot in A the values of the statistics Fsi′ and Fsd′ with colors corresponding to the selection coefficients s, as well as the values calculated for the real trajectory of the H275Y oseltamivir resistance mutation in black. We indicate the region corresponding to the best 1% retained simulations with a dashed line, and plot the corresponding two-dimensional posterior distribution for s and Ne in B.