Influenza Virus Drug Resistance: A Time-Sampled Population Genetics Perspective (original) (raw)
Figure 5
Log-likelihood contours for the H275Y resistance mutation in the presence of oseltamivir.
We plot the two-dimensional likelihood surface for the selection parameter γ = Ne .s (x-axis) and the allele age t0 (y-axis) in generations, with generation zero representing the end of the experiment. Horizontal black lines represent sampling times. The colors indicate the value of the log-likelihood, with red being the highest and blue being the lowest. The maximum likelihood is shown as a black dot, and the log likelihood was lowered from its peak by /2 = 2.996, to construct a 95% confidence (likelihood) region for the parameters (dashed black line).