Mediation Analysis Demonstrates That Trans-eQTLs Are Often Explained by Cis-Mediation: A Genome-Wide Analysis among 1,800 South Asians (original) (raw)
Figure 4
The impact of _cis_-transcript measurement error and LD on evidence for mediation based on simulated data.
When the effect of a genetic variant on a _trans_-gene is completely mediated by a _cis_-transcript, evidence of mediation decreases, in terms of the “proportion of signal that is mediated” (left) and the Sobel P (right), as measurement error increases and as the LD between the causal and measured variant decreases.