Time Course and Cellular Localization of SARS-CoV Nucleoprotein and RNA in Lungs from Fatal Cases of SARS (original) (raw)
Figure 3
Colocalization of SARS-CoV Infection of Human Lung Tissues
Shown are tissue samples stained with SARS-CoV monoclonal nucleocapsid FITC and epithelial membrane antigen TRITC. At day 5 postinfection, there is positive staining of type 1 pneumocytes (A), with epithelial cell debris present in the alveolar lumen (B). In one case (TO case 1), there is positive staining for SARS-CoV of the type 1 pneumocytes with no staining of CD68 positive macrophages (C and D). HK case 1, however, shows FITC staining within the cytoplasm of CD68-positive cells (E).