Gene Expression Programs in Response to Hypoxia: Cell Type Specificity and Prognostic Significance in Human Cancers (original) (raw)
Figure 4
The Analysis of Hypoxia Response in Human Cancers
The expression values of genes in the “epithelial cell hypoxia signature” were extracted from an expression study of 41 renal tumors (A) [28]. Genes and samples are organized by hierarchical clustering. The tumors are segregated into two groups defined by high (blue) or low (red) hypoxia response. The histopathological features of renal tumors within the high and low hypoxia response groups are shown. Expression patterns of available “epithelial hypoxia response” genes in a group of breast cancer samples from Norway and Stanford (B) [29] and NKI (C) [47] as well as ovarian cancer samples (D) are shown. The tumors are separated into two groups based on their hypoxia responses, high or low. Kaplan-Meier curves for the clinical outcomes of indicated tumors exhibiting high and low hypoxia responses are shown in (B), (C), and (D). In the Kaplan-Meier curve diagrams, high hypoxia response is indicated by blue, low hypoxia response is indicated by red, and censored patients are indicated with “x” marks. The correlation between the average hypoxia response and HIF-1α RNA levels in 70 ovarian cancer samples is shown in (E).