Silencing Viral Infection (original) (raw)
Figure 1
Possible Targets for Suppressing HIV Replication
siRNAs can be used to silence either viral mRNAs or host genes required for viral entry or replication. This figure shows some possible targets for suppressing HIV replication. Silencing CCR5 can prevent viral entry, while any viral gene can also be silenced to interfere with viral production. siRNAs could also target the viral long term repeat or even the proviral genomic RNA prior to integration, although whether this can be done is controversial. Targeting multiple genes will enhance viral suppression and reduce the chances of viral escape by sequence mutation.