Combining Information from Common Type 2 Diabetes Risk Polymorphisms Improves Disease Prediction (original) (raw)

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Figure 1

Power to Detect Interaction ORs for Combinations of SNPs

The power calculations assume a multiplicative mode of inheritance. Estimates of allele frequencies and expected effect size were determined from the literature; our study frequencies and effects sizes are consistent with these. α was set at 0.05. The power calculations were performed using Quanto [22].

Figure 1

doi: https://doi.org/10.1371/journal.pmed.0030374.g001