Modelling the Impact of Artemisinin Combination Therapy and Long-Acting Treatments on Malaria Transmission Intensity (original) (raw)
Figure 5
Model-Estimated Impact of Introducing Antimalarials with 100% Efficacy and Different Pharmacodynamic Properties
Impact is shown on (A) clinical episodes and (B) slide-prevalence of infection in six transmission settings in Tanzania, compared to the pre-ACT scenario with failing nonartemisinin treatment assuming a 100% switch to these treatments. Short-acting nongametocytocidal: prophylactic time = 10 d, no specific gametocytocidal action. Short-acting ACT (as Figure 3A): prophylactic time = 10 d, with the gametocytocidal action of artemisinin. Long-acting nongametocytocidal: prophylactic time = 25 d, no specific gametocytocidal action. Long-acting ACT: prophylactic time = 25 d, with the gametocytocidal action of artemisinin.