The Potential Impact of Density Dependent Fecundity on the Use of the Faecal Egg Count Reduction Test for Detecting Drug Resistance in Human Hookworms (original) (raw)
Figure 2
Examination of N. americanus egg output data from Hill [18].
A = egg output per female worm for the 93 human cases; x = cases with <500 females (n = 82); ▪ = cases with >500 females (n = 11) (see text for details). B: Relationship between % FECR in response to treatment with a drug of known efficacy for the human cases in the < or > 500 female groups; ▪ dotted line: cases with pretreatment female numbers <500 (assuming no increase in egg output per female after treatment) (n = 82); ▾solid line: cases with pretreatment female numbers >500 (assuming post treatment egg output per female equals the median of the <500 group) (n = 11); ○ dashed line: all cases combined (n = 93). % FECR is based on a simple model in which the worms surviving the drug treatment in the >500 group from A are able to increase their egg output to match the median output of the <500 group from A, while the <500 output group show no change in output following drug treatment. Each data point represents mean±SE (n = 82, 11 or 93) (see text for details).