Schistosoma mansoni Tegument Protein Sm29 Is Able to Induce a Th1-Type of Immune Response and Protection against Parasite Infection (original) (raw)
Figure 4
Sm29 induces IL-12 and TNF-α production by macrophages from TLR4 knockout mice.
Levels of IL-12 (p40) (A) or TNF-α (B) were measured in the supernatants of inflammatory macrophages from TLR4 KO or wild-type mice stimulated for 24 hrs with rSm29 (25 μg/ml), E. coli LPS (1 μg/ml) or medium alone. Significant differences from stimulated TLR4 KO or C57BL/6 macrophages in relation to non-stimulated cells are denoted by an asterisk (*) for p<0.05.