Attenuation of Toll-Like Receptor Expression and Function in Latent Tuberculosis by Coexistent Filarial Infection with Restoration Following Antifilarial Chemotherapy (original) (raw)
Figure 1
Filarial infection is associated with decreased expression of TLR2 and TLR9 at baseline and following PPD and CFP stimulation in latent TB patients.
PBMC from PPD+Fil− (n = 9) and PPD+Fil+ (n = 9) patients were examined at baseline (A) or stimulated with PPD (B) or Mtb CFP (C) or TT (D) for 24 hours, and TLR1, 2, 4, and 9 mRNA levels were measured by real-time RT-PCR. Results are shown as relative expression at baseline (A) or fold change over media control (B, C, and D). p values were calculated using the Mann-Whitney test.