Attenuation of Toll-Like Receptor Expression and Function in Latent Tuberculosis by Coexistent Filarial Infection with Restoration Following Antifilarial Chemotherapy (original) (raw)
Figure 2
Filarial infection is associated with diminished cytokine responses to TLR2 and TLR9 ligands in latent TB patients.
PBMC from PPD+Fil− (n = 9) and PPD+Fil+ (n = 9) patients were stimulated with TLR2 ligand (Pam3Cys) (A) or TLR9 ligand (ODN) (B) or TLR4 ligand (LPS) (C) for 24 hours, and IL-1β, TNF-α, IL-6, IL-12p70, and IFN-γ cytokine levels were measured by ELISA. Results are shown as net cytokine production over media control. P values were calculated using the Mann-Whitney test.