The New Anthelmintic Tribendimidine is an L-type (Levamisole and Pyrantel) Nicotinic Acetylcholine Receptor Agonist (original) (raw)
Figure 6
trb mutants are quantitatively resistant to levamisole.
Mortality of wild-type (wt) N2 and trb-1, -2, -3, and -4 mutant animals exposed to varying doses of levamisole for 6 days at 25°. Each data point represents on average 180 worms (n = 3 repeats; 3 replicate wells per repeat). Error bars represent standard error of the mean for the three independent experiments. Allele designations are as in Figure 1. The LC50 value for each genotype is reported in Table 2. For converting to a mM dose, 100 µg/mL levamisole is equivalent to 0.42 mM.