The New Anthelmintic Tribendimidine is an L-type (Levamisole and Pyrantel) Nicotinic Acetylcholine Receptor Agonist (original) (raw)
Figure 7
Mutations in trb-1(ye492) are associated with exon/intron boundaries of the unc-63 gene.
Above, nucleotide sequence of the unc-63 gene at the exon 9/intron 9 and intron 9/exon 10 boundaries. Below, three altered nucleotides in trb-1(ye492) as indicated by down arrows. Assuming the mutant intron is not spliced, then inclusion of intron 9 would result in a translated protein with two missense mutations at amino acids 458 and 459 followed by a premature stop codon (the full length protein is normally 502 aa).