Identification of Attractive Drug Targets in Neglected-Disease Pathogens Using an In Silico Approach (original) (raw)
Figure 2
A summary of the multiparameter search queries presented in this study.
Ten different queries (Queries 2–11) are listed as individual columns for which the criteria are shown on the left. For each criterion, the number of qualifying proteins from a given pathogen is shown in black and the associated weight is shown in red within parentheses. Symbols: (#) enzymes were selected by combining searches by EC number and by functional category, except for Queries 10 and 11, which were based only on EC number; (&) the conserved-in-taxon criterion refers to the presence of orthologs in L. major, T. brucei, and T. cruzi (Tables 2 and 3), P. falciparum and P. vivax (Tables 4 and 7), M. tuberculosis and M. leprae (Table 5), and L. major and T. cruzi (Table 8); (¶) druggability and compound desirability scores were queried using respective cutoff values of ≥0.6 and >0.3 (Tables 2 to 5), ≥0.4 and >0.2 (Tables 6 and 7), and ≥0.5 (druggability scores only; Table 8).