Dual Targeting of Insulin and Venus Kinase Receptors of Schistosoma mansoni for Novel Anti-schistosome Therapy (original) (raw)
Figure 4
Dose-dependent effect of AG1024 on viability of cultured schistosomula of S.mansoni.
(A) Viability of schistosomula cultured for 5 days without or with 1, 10, 20 or 50 µM of AG1024. Results are expressed as % of surviving larvae (mean ±SD, three independent experiments). (B) Morphological examination of schistosomula following 48 h incubation with 10, 20 and 50 µM AG1024. All schistosomula died within 48 h with 50 µM AG1024, characterized by their dark appearance, granular aspect and tegumental abnormalities.