Host Immune Responses Differ between M. africanum- and M. tuberculosis-Infected Patients following Standard Anti-tuberculosis Treatment (original) (raw)
Fig 5
Kinetics of gene expression in Maf- and _Mtb_-infected groups following treatment.
The expression kinetics of genes that showed significant differences between Maf- and _Mtb_-infected groups following overnight incubation with Medium alone (A), ESAT-6/CFP-10 (B) and live Maf (C). Line plots show the predicted mean and its 95% CI of log2 transformed gene expression levels in Maf- and _Mtb_-infected groups at 0, 2 and 6 months of treatment. Wald test through contrasts analysis following a random-intercept model adjusted for age, sex and ethnicity was used to assess interaction between lineage group and time point on gene expression. The legend shows Maf-infected group (dashed lines) and Mtb-infected group (solid lines) respectively. P-values of the interactions are shown.