Identification of CD133-Positive Radioresistant Cells in Atypical Teratoid/ Rhabdoid Tumor (original) (raw)
Figure 4
Evaluation of radiosensitivity in C133+/− AT/RT cells in vitro and in vivo.
(A) The survival fraction of CD133+/− AT/RT cells after IR treatment. The IR dose: from 0 to 10 Gy. (B) Detection by immunohistochemistry of CD133+ AT/RT cells in the tissue samples of the same patient after the first surgery and the second surgery (tumor recurrence) (bar: 50 µm). (C) The percentage of CD133+ AT/RT cells (1st surgery: 9 patients) was dramatically elevated in the tumor relapse samples (2nd surgery: 5 patients). (D) Comparison of the tumor samples from the first and second surgeries in the five patients whose tumors relapsed. *p<0.05; **p<0.001. Data shown here are the mean±SD of three experiments.