Contextual Specificity in Peptide-Mediated Protein Interactions (original) (raw)
Figure 3
Topological variation of peptides binding human SH3 domains.
One domain is shown for each of the two possible orientations of SH3-binding peptides, in surface representation. Native and non-native peptides for class I (pattern [RKY]xxPxxP, left) and class II (pattern PxxPx[KR], right) are shown as ribbons. Key residues are highlighted as sticks. The first and last highlighted residues delimit the motifs; everything N- and C-terminal of that, respectively, is context. Both domains have a similar orientation in the figure, so, as the peptides have opposite orientations, the N-termini of the class I peptides are on the left, while those of the class II peptides are on the right.