Molecular Subsets in the Gene Expression Signatures of Scleroderma Skin (original) (raw)
Figure 4
Scleroderma Module Map.
A. Module map of the Gene Ontology (GO) Biological Processes differentially expressed among the scleroderma samples is shown. Each column represents a single microarray and each row represents a single GO Biological process. Patient samples are organized as described in Figure 2. Only modules that were significantly enriched (minimum 2-fold change, p<0.05) on at least 4 micoarrays are shown. The average expression of the gene hits from each enriched gene set is displayed here. Only gene sets that show significant differences after multiple hypothesis testing were included. Select GO biological processes are shown. The entire figure with all biological processes can be viewed in Supplementary Figure S4. B. Module map using gene list created from an experimental identification of all cell cycle-regulated genes [49] and genes found to be expressed in specific lymphocyte subsets [64].