Fibrotic Myofibroblasts Manifest Genome-Wide Derangements of Translational Control (original) (raw)
Figure 5
Systems analysis of pathway activities and myofibroblast origin.
Pathways are shown in rows and conditions are shown in columns. A red box denotes that the pathway is activated in IPF compared with control myofibroblasts; green boxes represent pathways that are activated in controls compared to IPF myofibroblasts. Blue boxes signify a pathway that is activated both in IPF compared to controls and controls compared to IPF, and gray boxes represent pathways with no significant activity. This analysis was performed using cells in non-contractile matrices setting the threshold at a FDR<0.05, (“TF” = transcription factors). Pathways ending with “.go” were obtained from GO. EMT pathways were manually constructed while all other pathways were obtained from KEGG.