Cancer Genes Hypermethylated in Human Embryonic Stem Cells (original) (raw)
Figure 5
Proposed model of aberrant methylation in cancer for genes frequently hypermethylated in stem cells in vivo.
The loss of promoter hypermethylation might be necessary for overexpression of a subset of Class B genes during differentiation. The aberrant process in cancer for these genes should be understood as a defect in establishing an unmethylated promoter during differentiation, rather than as an anomalous process of de novo hypermethylation.