Genetic Disruption of Both Tryptophan Hydroxylase Genes Dramatically Reduces Serotonin and Affects Behavior in Models Sensitive to Antidepressants (original) (raw)
Figure 4
Immobility and struggling in the forced swim test.
(A) TPH2KO Males. (B) TPH2KO Females. (C) TPH1/TPH2 DKO Males. (D) TPH1/TPH2 DKO Females. *** - p<0.001, ** - P<0.01, * - p<0.05 compared to WT mice (unpaired t-test).