Accuracy of Predicting the Genetic Risk of Disease Using a Genome-Wide Approach (original) (raw)
Figure 2
Predicted accuracy of estimated genetic risk from population and case control designs of a dichotomous phenotype.
Contour plot of predicted accuracy for varied prevalence and additive heritability on the observed scale, in population studies (dashed vertical line) and case control studies (solid line) of dichotomous phenotypes. Each contour represents a line of constant accuracy, starting from the right 0.9, 0.8, 0.7, and 0.6. The narrowly dashed line is derived from Equation (5) with , so values below this line are not possible under the liability model.