Structures of SRP54 and SRP19, the Two Proteins that Organize the Ribonucleic Core of the Signal Recognition Particle from Pyrococcus furiosus (original) (raw)
Figure 1
The archeal Signal Recognition Particle.
(A) Simplified schematic of the archaeal signal recognition particle from Pyrococcus furiosus. (B) The sequence and organization of the core of the SRP RNA are shown with helices 6 and 8, the respective binding sites for the proteins SRP19 and SRP54/Ffh. For SRP54/Ffh the M domain, responsible for both SRP RNA and signal sequence recognition, is connected to the NG domain with the GTPase activity, through a flexible linker (in magenta). Although the NG of SRP54 domain has also been shown to interact loosely with the core of the SRP RNA, for the sake of clarity this is not represented on this schematic.