Genomic Convergence Analysis of Schizophrenia: mRNA Sequencing Reveals Altered Synaptic Vesicular Transport in Post-Mortem Cerebellum (original) (raw)
Figure 3
Comparison of Mahalanobis Distances of Gene Expression by Array Hybridization and Sequence Read Frequencies.
14 SCZ samples are indicated by blue circles, and 6 control samples by red circles. The Y-axis shows Mahalanobis distances of log transformed gene expression values. The dotted blue line indicates the cutoff value for outliers. Panel A: Log10 transformed Affymetrix array hybridization signals. Panel B: Log10 transformed genome-aligned read frequencies. Panel C: Log10 transformed transcript-aligned read frequencies. Log10 transformed array hybridization values (A) had a wider distribution of distances than Log10 transformed sequence read frequencies (B,C). Without log transformation, distances were greater and several samples represented outliers (data not shown).