Genomic Convergence Analysis of Schizophrenia: mRNA Sequencing Reveals Altered Synaptic Vesicular Transport in Post-Mortem Cerebellum (original) (raw)
Figure 10
Cartoon illustrating functions and/or synaptic locations of 23 proteins corresponding to genes with altered expression in SCZ.
15 genes were upregulated (green), whereas 8 were downregulated (red). Underlined genes had >30% change in expression. Two genes involved in transport from the endoplasmic reticulum to the Golgi (GOLM1 and GPSN2) were downregulated, ten involved in transport from the trans-Golgi network to the synaptic vesicle were upregulated (GOLGA1, SLC35A3, COG6, TRIP11, AP1G1, ARFGEF2, USO1, ROCK1, RAB9B and VPS35) and two were downregulated (STX10 and ARFRP1), two genes involved with synaptic vesicle exocytosis (EEA1 and SYT1) were upregulated and two were downregulated (SV2A and NCDN), one gene involved in receptor-mediated endocytosis was upregulated (AAK1) and one involved in retrograde transport back to the Golgi apparatus was downregulated (SNX17). In addition, three post-synaptic membrane genes showed altered expression: GABRA1 (upregulated), ZACN (downregulated) and CACNG2 (upregulated).