Prdm Proto-Oncogene Transcription Factor Family Expression and Interaction with the Notch-Hes Pathway in Mouse Neurogenesis (original) (raw)
Figure 5
Expression of Prdm family genes in the early postnatal brain.
Coronal sections through P6 brains, processed to show Prdm8 expression (A, D, E), Prdm12 expression (H, I), Tbr1 expression (C, F) or Nissl (B, G). Prdm8 is expressed in layer 2/3 and 4 of the neocortex (A). Nissl stain clearly reveals the cortical layers, especially the barrel hollows in the somatosensory cortex in layer 4 (B, arrowheads). Layer 2/3, 5, and 6 are specifically labelled by Tbr1 (C). Cells expressing Prdm8 in the hippocampus are concentrated in the dentate gyrus (DG) and the CA2/3 regions (D). At P6, Prdm8 is expressed specifically in nucleus of lateral olfactory tract (nLOT) (E), which is also revealed by Tbr1 (F) and Nissl staining (G). Prdm12 expression in the hypothalamus is restricted in dorsomedial nucleus (H). In the thalamus, expression of Prdm12 is specific to the dorsal half of the zona incerta (I, arrows). Scale bar in C is 500 µm for A–H and 1.3 mm for I.