Prdm Proto-Oncogene Transcription Factor Family Expression and Interaction with the Notch-Hes Pathway in Mouse Neurogenesis (original) (raw)
Figure 6
Prdm8 is upregulated, and Prdm16 downregulated, in _Hes_-null forebrain.
Coronal sections of wildtype (A, C, E) and Hes cTKO (B, D, F) E14.5 telencephalon with ISH to detect Prdm8 (A, B), Ngn2 (C, D), and Prdm16 (E, F). Prdm8 and Ngn2 are upregulated in developing _Hes_-null brains. This upregulation is due to more cells expressing Prdm8 (compare A′ and B′, which are magnified regions of the boxed areas in A and B respectively) and Ngn2 (compare the brackets in C and D). On the other hand, Prdm16 is strongly downregulated in the subpallium (blue arrowheads) and slightly downregulated in the pallium (purple arrowheads). Scale bar in A, 500 µm.