Ser276 Phosphorylation of NF-kB p65 by MSK1 Controls SCF Expression in Inflammation (original) (raw)
Figure 5
Pathway leading to SCF expression in primary human lung fibroblasts upon IL-1β treatment.
After treatment with IL-1β, both p38 and ERK MAPK activate MSK1 which phosphorylates nuclear p65 at Ser276. This leads to binding of NF-κB p65 to the κB site of the SCF intronic enhancer, and to interaction with the coactivator CBP. Phosphorylation of histone H3 at Ser10 upon IL-1β-treatment is mediated through a MSK1-independent pathway. IL-1β: interleukin-1β; IL-1R: interleukin-1 receptor; ERK: extracellular signal regulated kinase; MAPK: mitogen-activated protein kinase; NF-κB: nuclear factor-κB; IκB: inhibitor of NF-κB; MSK1: mitogen- and stress-activated protein kinase 1; CBP: CREB binding protein; H3: histone 3.