CFTR Is a Negative Regulator of NFκB Mediated Innate Immune Response (original) (raw)
Figure 2
CFTR downregulates IL-8 chemokine secretion.
CFBE41o- control and cells stably transduced with wt-CFTR were induced with 1 ng/ml IL1-β and IL-8 chemokine secretion in media was calculated after overnight treatment. Data are shown as mean±SD of three experiments. IL1-β stimulates IL-8 chemokine secretion while wt-CFTR blunts both control and IL1-1β driven IL-8 chemokine secretion (*p<0.05).