Host Genetic Background Strongly Influences the Response to Influenza A Virus Infections (original) (raw)
Figure 5
DBA/2J mice are highly susceptible to H7N7 (SC35M) virus infection compared to C57BL/6J mice.
(A): DBA/2J and C57BL/6J mice were infected intra-nasally with 2×103 FFU SC35M virus. DBA/2J (B) and C57BL/6J (C) mice were infected with increasing doses of SC35M (H7N7) virus via the intra-nasal route. Weight loss and survival of infected mice was followed over a period of 14 days. Mortality includes also mice that were sacrificed because they had lost more than 25% of body weight. Data are from two independent experiments. Mean percent of body weight change (±SEM) is shown. DBA/2J and C57BL/6J groups were compared for statistically significant differences using non-parametric Mann-Whitney-U-test. *: p value<0.05; **: p<0.01; ***: p value<0.001.