Evaluation and Characterization of Bacterial Metabolic Dynamics with a Novel Profiling Technique, Real-Time Metabolotyping (original) (raw)
Figure 4
Time series of STOCSY analysis of B. fibrisolvens MDT-10 incubated with LNA.
During these one-hour experiments, a total of twelve continuously acquired in vivo 1H-NMR spectra were used for STOCSY analysis. Spectra appearing on the right side are the sum of the twelve in vivo 1H-NMR spectra measured in every one-hour experiment. Contour levels (STOCSY correlations) defined by different colors are indicated at the bottom. Blue represents high positive correlation and red represents low. Optical density (OD) is a measure of bacterial growth. Arrows indicate butyrate (black), lactate (orange), acetate (pink), and ethanol (purple). Signals surrounded by green squares are assumed to be derived from LNA or its metabolites. Data are representative of three independent experiments.