BDNF Activates mTOR to Regulate GluR1 Expression Required for Memory Formation (original) (raw)
Figure 3
mTOR Signaling Is Required for IA Memory Consolidation During Two Restricted Time Windows After Training.
Data are expressed as mean (±SEM) of training (TR, black bars) or test session step-down latency at 24 h (A) or 7 days (B) after IA training. Animals were infused intra-CA1 of the dorsal hippocampus with vehicle (Vh, light grey bars) or rapamycin (4.3 pg/side, dark grey bars), 15 min before or 0, 1, 3, 9, and 12 h after training. Inlet: Rats were infused into the dorsal hippocampus with rapamycin (4.3 pg/side) or vehicle and sacrificed 15 min after drug infusion for analysis of p70S6K activation in the dorsal hippocampus by Western blot. Bars represent the p-p70S6K/p70S6K ratio of rapamycin (white) respect to vehicle (black) treated rats. *p<0.05, **p<0.01, ***p<0.001 vs. Vh for each time point, n = 8–10 per group for each experiment in A and B and n = 5 per group in the inlet.